Endocrine Abstracts

Gastric bypass surgery (GBP) promotes early benefits in energy homeostasis in obese diabetic patients, including decreased hunger and improved glucose control. A suggested mechanism associates a decrease in hepatic glucose production (HGP) with an enhanced intestinal gluconeogenesis (IGN), the latter promoting metabolic benefits in energy homeostasis. In addition, bile acids (BA) have emerged as key metabolic regulators, which might account for several anti-diabetic effects. M...

The extrinsic gastrointestinal nervous system plays a key role in the sensing of nutrients and hormones and its translation in terms of control of food intake by the CNS. Regarding major macronutrients as glucose and protein, they are sensed by the gastrointestinal neural system and the transmission of the signals to the brain promotes satiety phenomena. Glucose is sensed in the portal vein by neurons expressing the glucose receptor SGLT3 and activates the main regions of the ...